Serotonin/5-hydroxytryptamine (5-HT) physiology
نویسندگان
چکیده
منابع مشابه
Temporal regulation of agonist efficacy at 5-hydroxytryptamine (5-HT)1A and 5-HT 1B receptors.
Coactivation of purinergic (P 2Y) receptors reduces agonist efficacy at serotonin 1B (5-HT 1B), but not 5-HT 1A receptors. Herein, we report that pretreatment for 5 min with the P 2Y receptor agonist ATP reduced agonist responsiveness at the 5-HT 1A, but not at the 5-HT 1B, receptor. The effect of ATP pretreatment on the 5-HT 1A receptor response rapidly reversed within a 10 min time frame betw...
متن کاملRelationship between neonatal testosterone and 5-hydroxytryptamine (5 HT) in controlling the pattern of LH release in adult rats
Relationship between neonatal testosterone and 5-hydroxytryptamine (5-HT) in controlling the pattern of LH release in adult rats was investigated in this study. Hypothalamic 5-HT concentrations are transiently lower in male as compared to female Wistar rats in the second week post-partum (pp). It has also been shown that pharmacologically potentiating 5-HT activity during this period feminizes ...
متن کاملReduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice.
The aim of the present study was to determine whether alterations in 5-hydroxytryptamine (5-HT)(1A) receptors would be found in knockout mice lacking the serotonin transporter (5-HTT). Hypothermic and neuroendocrine responses to the 5-HT(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT) were used to examine the function of 5-HT(1A) receptors. Initial studies evaluated the dose-res...
متن کاملRegulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT(1A) and 5-HT(1B) receptors.
The ability of selective serotonin (5-HT) receptor agonists to reduce the extracellular concentration of 5-HT was examined in the striatum of awake, unrestrained mice by in vivo microdialysis. Systemic administration of either 8-OH-PIPAT (R-(+)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)] aminotetralin), a novel 5-HT(1A) receptor agonist, or CP 94,253, a selective 5-HT(1B) receptor ag...
متن کاملRelationship between neonatal testosterone and 5-hydroxytryptamine (5 HT) in controlling the pattern of LH release in adult rats
Relationship between neonatal testosterone and 5-hydroxytryptamine (5-HT) in controlling the pattern of LH release in adult rats was investigated in this study. Hypothalamic 5-HT concentrations are transiently lower in male as compared to female Wistar rats in the second week post-partum (pp). It has also been shown that pharmacologically potentiating 5-HT activity during this period feminizes ...
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ژورنال
عنوان ژورنال: Southern African Journal of Anaesthesia and Analgesia
سال: 2020
ISSN: 2220-1173,2220-1181
DOI: 10.36303/sajaa.2020.26.6.s3.2561